1986

• Developed the earliest domestically available isoenzyme electrophoresis monitoring technique for genetic quality of experimental rats, laying the foundation for establishing national standards for genetic quality testing of laboratory rats.

2005

• Achieved the development of China's first "Experiment Animal Information Management System," significantly enhancing the efficiency of production, management, and sales of laboratory animals, while reducing error rates.

2006

• Successfully developed the world's first "Morphological Measurement and Analysis System for Mandibular Characteristics of Mus and Rattus species," utilizing a computer-assisted system to classify and analyze morphological features within these rodent species.

2009

• Successfully bred China's first pathogen-free  mouse colony, filling a critical gap in the country’s sterile animal resources. This achievement provided substantial support for advancements in gut microecology and immunology research.

2011

• Successfully cultivated China's first proprietary inborn congenital cataract mouse model（BALB/cAn-Crygc^m1Sbao/Slac）

  
  

2012

• In collaboration with Donghua University, established the country's first SNP molecular genetic detection technology and method for laboratory mice, ensuring that China’s genetic quality testing of laboratory mice remains synchronized with international standards.

2013

• Partnering with the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, employed CRISPR-Cas9 technology to inject Cas9 mRNA and target gene fragments into fertilized eggs of the congenital cataract mouse model (BALB/cAn-Crygc^m1Sbao/Slac). The gene Crygc^m1Sbao was repaired during embryonic development, resulting in the successful birth of genetically normal mice, thus providing a new technical approach for gene therapy research.

2019

• Successfully bred China’s first inborn late-onset cataract mouse model (approximately 50 days after birth), temporarily named the FVB/NJ-Cat/Slac Model for Late-Onset Cataract Disease.

2020

• Utilized CRISPR/Cas9 gene editing technology to knock out three genes—Rag1-/-, Rag2-/-, and Il2rg-/-—and successfully developed T, B, and NK immune cell-deficient rats (SD-RG) through targeted breeding.